NKX3-1 antibody (AA 1-100)

Catalog No. ABIN8123352

The Mouse Monoclonal anti-NKX3-1 antibody is suitable to detect NKX3-1 in samples from Human. It has been validated for IHC, WB, ELISA and IF.

Quick Overview for NKX3-1 antibody (AA 1-100) (ABIN8123352)

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NKX3-1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Western Blotting (WB), ELISA, Immunofluorescence (IF)

Clone: AB1400

Product Details anti-NKX3-1 Antibody

Binding Specificity: AA 1-100

Purpose: NKX3.1 mouse mAb

Specificity: The antibody can specifically recognize human NKX3. 1 protein.

Purification: The antibody was purified by protein G affinity chromatography.

Immunogen: A synthetic peptide corresponding to the amino acid region 1 - 100 of the human NKX3. 1 protein.

Isotype: IgG

Application Details

Application Notes: IHC, 1:200-1:1000 | WB, 1:500-1:2000 | IF, 1:100-1:500 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for NKX3-1

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Alternative Name: NKX3.1

Background:

Synonyms: BAPX 2, BAPX2, Homeobox protein NK-3 homolog A, Homeobox protein Nkx 3. 1, Homeobox protein Nkx-3. 1, Homeobox protein Nkx3. 1, NK homeobox (Drosophila) family 3 A, NK homeobox family 3 A, NK homeobox, family 3, member A, NK3 homeobox 1, NK3 transcription factor homolog A, NK3 transcription factor related locus 1, NKX 3, Nkx 3. 1, NKX 3A, NKX3 1, NKX3, Nkx3-1, NKX3. 1, Nkx3. 1, Mouse, homolog of, NKX31_HUMAN, NKX3A

Background: NKX3. 1 is a nuclear transcription factor and a negative regulator of the growth of prostatic epithelial cells. Its mRNA transcription level is regulated by androgens and plays an important role in the occurrence and differentiation of prostate organs and the maintenance of the function of mature organs. NKX3. 1 has high sensitivity and specificity in benign prostatic hyperplasia and prostate cancer, and can be used as one of the specific markers to distinguish prostate cancer, benign prostatic hyperplasia and non prostate cancer. It is also expressed in mucous glands of testis, ureter and pulmonary bronchus.

Gene Name: NKX3-1

Protein Name: NKX3. 1

Gene ID: 4824

UniProt: Q99801

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Endopeptidase Activity, Positive Regulation of Response to DNA Damage Stimulus