NAIP antibody (AA 1191-1240)

Catalog No. ABIN8123355

The Rabbit Polyclonal anti-NAIP antibody is suitable to detect NAIP in samples from Human and Mouse. It has been validated for IHC, ELISA and IF.

Quick Overview for NAIP antibody (AA 1191-1240) (ABIN8123355)

Target: NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NAIP antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Product Details anti-NAIP Antibody

Binding Specificity: AA 1191-1240

Purpose: NAIP Antibody

Specificity: The antibody detects endogenous NAIP

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthetic peptide from human protein at AA range: 1191-1240

Isotype: IgG

Application Details

Application Notes: IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for NAIP

Target: NAIP (NLR Family, Apoptosis Inhibitory Protein (NAIP))

Alternative Name: NAIP

Background:

Synonyms: Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein)

Background: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This copy of the gene is full length, additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. It is thought that this gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1.The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by Ref

Gene Name: NAIP BIRC1

Protein Name: Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein)

Gene ID: 4671

UniProt: Q13075

Pathways: Apoptosis, Inflammasome