NOTCH4 antibody (Cleaved-Val1467)

Catalog No. ABIN8123380

The Rabbit Polyclonal anti-NOTCH4 antibody (ABIN8123380) specifically detects NOTCH4 in WB and ELISA. The antibody is reactive with Human and Monkey samples.

Quick Overview for NOTCH4 antibody (Cleaved-Val1467) (ABIN8123380)

Target: NOTCH4 (Notch 4 (NOTCH4))

Reactivity: Human, Monkey

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOTCH4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-NOTCH4 Antibody

Binding Specificity: Cleaved-Val1467

Purpose: NOTCH4 (Cleaved-Val1467) Antibody

Specificity: This antibody detects endogenous levels of Human,Monkey NOTCH4 (Cleaved-Val1467, protein was cleaved amino acid sequence between 1466-1467 )

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human NOTCH4 (Cleaved-Val1467)

Isotype: IgG

Application Details

Application Notes: WB 1:1000-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for NOTCH4

Target: NOTCH4 (Notch 4 (NOTCH4))

Alternative Name: NOTCH4

Background:

Synonyms: Neurogenic locus notch homolog protein 4 (Notch 4, hNotch4) [Cleaved into: Notch 4 extracellular truncation, Notch 4 intracellular domain]

Background: notch 4(NOTCH4) Homo sapiens This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor may play a role in vascular, renal and hepatic development. Mutations in this gene may be associated with schizophrenia. Alternative splicing results in multiple transcript variants, at least one of which

Gene Name: NOTCH4 INT3

Protein Name: NOTCH4 (Cleaved-Val1467)

Gene ID: 4855

UniProt: Q99466

Pathways: Notch Signaling