Perforin 1 antibody (AA 1-100)

Catalog No. ABIN8123649

The Mouse Monoclonal anti-Perforin 1 antibody is suitable to detect Perforin 1 in samples from Human. It has been validated for IHC.

Quick Overview for Perforin 1 antibody (AA 1-100) (ABIN8123649)

Target: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Perforin 1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: AB1570

Product Details anti-Perforin 1 Antibody

Binding Specificity: AA 1-100

Purpose: Perforin mouse mAb

Specificity: The antibody can specifically recognize human Perforin protein.

Purification: The antibody was purified by affinity chromatography using a specific immunogen.

Immunogen: A synthetic peptide corresponding to the amino acid region 1 - 100 of the human Perforin protein.

Isotype: IgG

Application Details

Application Notes: IHC, 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at-20°C. Avoid freeze / thaw cycles.

Target Details for Perforin 1

Target: Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))

Alternative Name: Perforin

Background:

Synonyms: Cytolysin, FLH2, HPLH2, Lymphocyte pore-forming protein, P1, PERF_HUMAN, perforin 1 (pore forming protein) , Perforin 1, Perforin-1, PFP, PGFL, PIGF, PIGF-2, PLGF, Pore forming protein, prf1, SHGC-10760

Background: Perforin is a specific marker of activated cytotoxic T cells and natural killer cells. It can destroy the corresponding target cell membrane and induce apoptosis. It is mainly expressed in CD3 negative and CD56 positive NK cells, CD3 positive large granular lymphocytes and γδ Type T cells. It is mainly used for the auxiliary diagnosis of NK cell lymphoma and NK cell like T-cell lymphoma.

Gene Name: PRF1 PFP

Protein Name: Perforin

Gene ID: 5551

UniProt: P14222

Pathways: Apoptosis, Caspase Cascade in Apoptosis