POLM antibody (AA 210-290)

Catalog No. ABIN8123860

The Rabbit Polyclonal anti-POLM antibody (ABIN8123860) specifically detects POLM in WB and ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for POLM antibody (AA 210-290) (ABIN8123860)

Target: POLM (Polymerase (DNA Directed), mu (POLM))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLM antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-POLM Antibody

Binding Specificity: AA 210-290

Purpose: DNA Pol μ Antibody

Specificity: DNA Pol μ Polyclonal Antibody detects endogenous levels of DNA Pol μ protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from DNA Pol mu . at AA range: 210-290

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for POLM

Target: POLM (Polymerase (DNA Directed), mu (POLM))

Alternative Name: DNA Pol mu

Background:

Synonyms: POLM, polmu, DNA-directed DNA/RNA polymerase mu, Pol Mu, Terminal transferase

Background: catalytic activity:Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).,cofactor:Magnesium.,function:Seems to act as an Ig mutase which is responsible for immunoglobulin (Ig) gene hypermutation.,similarity:Belongs to the DNA polymerase type-X family.,similarity:Contains 1 BRCT domain.,tissue specificity:Expressed in a number of tissues. Abundant in thymus.,

Gene Name: POLM

Protein Name: DNA-directed DNA/RNA polymerase mu

Gene ID: 27434

UniProt: Q9NP87

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response