Presenilin 2 antibody (AA 270-350)

Catalog No. ABIN8123929

The Rabbit Polyclonal anti-Presenilin 2 antibody (ABIN8123929) specifically detects Presenilin 2 in WB and IHC. The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for Presenilin 2 antibody (AA 270-350) (ABIN8123929)

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Presenilin 2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Presenilin 2 Antibody

Binding Specificity: AA 270-350

Purpose: Presenilin 2 Antibody

Specificity: This antibody detects endogenous levels of Human,Mouse,Rat Presenilin 2

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from human Presenilin 2 AA range: 270-350

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Presenilin 2

Target: Presenilin 2 (PSEN2) (Presenilin 2 (Alzheimer Disease 4) (PSEN2))

Alternative Name: Presenilin 2

Background:

Synonyms: Presenilin-2 (PS-2; EC 3.4.23.-; AD3LP; AD5; E5-1; STM-2) [Cleaved into: Presenilin-2 NTF subunit; Presenilin-2 CTF subunit]

Background: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq, Jul 2008],

Gene Name: PSEN2 AD4 PS2 PSNL2 STM2

Protein Name: Presenilin 2

Gene ID: 5664

UniProt: P49810

Pathways: Notch Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway