RFC1 antibody

Catalog No. ABIN8124313

The Rabbit Polyclonal anti-RFC1 antibody (ABIN8124313) specifically detects RFC1 in WB, ELISA and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for RFC1 antibody (ABIN8124313)

Target: RFC1 (Replication Factor C (Activator 1) 1, 145kDa (RFC1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RFC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-RFC1 Antibody

Purpose: RFC1 Antibody

Specificity: RFC1 Polyclonal Antibody detects endogenous levels of RFC1 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human RFC1.

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for RFC1

Target: RFC1 (Replication Factor C (Activator 1) 1, 145kDa (RFC1))

Alternative Name: RFC1

Background:

Synonyms: RFC1; RFC140; Replication factor C subunit 1; Activator 1 140 kDa subunit; A1 140 kDa subunit; Activator 1 large subunit; Activator 1 subunit 1; DNA-binding protein PO-GA; Replication factor C 140 kDa subunit; RF-C 140 kDa subunit; RFC140; Replication factor C large subunit

Background: This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011],

Gene Name: RFC1

Protein Name: Replication factor C subunit 1

Gene ID: 5981

UniProt: P35251

Pathways: Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA, Dicarboxylic Acid Transport