RFC1 antibody (Internal Region)

Catalog No. ABIN6264709

Product Details anti-RFC1 Antibody

Target: RFC1 (Replication Factor C (Activator 1) 1, 145kDa (RFC1))

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RFC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificity: RFC1 Antibody detects endogenous levels of total RFC1.

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human RFC1, corresponding to a region within the internal amino acids.

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20 °C. Stable for 12 months from date of receipt.

Expiry Date: 12 months

Target Details for RFC1

Target: RFC1 (Replication Factor C (Activator 1) 1, 145kDa (RFC1))

Alternative Name: RFC1 (RFC1 Products)

Synonyms: A1 antibody, MHCBFB antibody, PO-GA antibody, RECC1 antibody, RFC antibody, RFC140 antibody, AtRFC1 antibody, replication factor C 1 antibody, replication factor C1 antibody, 140kDa antibody, Alp145 antibody, Recc1 antibody, Replication factor C1 antibody, si:dkey-170e5.1 antibody, zgc:162875 antibody, replication factor C subunit 1 antibody, replication factor C1 antibody, replication factor C (activator 1) 1 antibody, DNA replication factor C complex subunit Rfc1 antibody, RFC1 antibody, Rfc1 antibody, rfc1 antibody

Background:

Description: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins PCNA and activator 1. This subunit binds to the primer-template junction. Binds the PO-B transcription element as well as other GA rich DNA sequences. Could play a role in DNA transcription regulation as well as DNA replication and/or repair. Can bind single- or double-stranded DNA.

Gene: RFC1

Molecular Weight: 128kDa

Gene ID: 5981

UniProt: P35251

Pathways: Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA, Dicarboxylic Acid Transport