SPHK1 antibody (pSer225)

Catalog No. ABIN8124895

The Rabbit Polyclonal anti-SPHK1 antibody (ABIN8124895) specifically detects SPHK1 in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for SPHK1 antibody (pSer225) (ABIN8124895)

Target: SPHK1 (Sphingosine Kinase 1 (SPHK1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPHK1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SPHK1 Antibody

Binding Specificity: pSer225

Purpose: SPHK1 (Phospho Ser225) Antibody

Specificity: This antibody detects endogenous levels of SPHK1 (Phospho-Ser225) at Human, Mouse,Rat

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human SPHK1 (Phospho-Ser225)

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for SPHK1

Target: SPHK1 (Sphingosine Kinase 1 (SPHK1))

Alternative Name: SPHK1

Background:

Synonyms: Sphingosine kinase 1 (SK 1) (SPK 1) (EC 2.7.1.91)

Background: The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011],

Gene Name: SPHK1 SPHK SPK

Protein Name: SPHK1 (Phospho-Ser225)

Gene ID: 8877

UniProt: Q9NYA1

Pathways: VEGF Signaling