Tryptophan Hydroxylase 2 antibody (pSer19)

Catalog No. ABIN8125415

This Rabbit Polyclonal antibody specifically detects Tryptophan Hydroxylase 2 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Tryptophan Hydroxylase 2 antibody (pSer19) (ABIN8125415)

Target: Tryptophan Hydroxylase 2 (TPH2)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tryptophan Hydroxylase 2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Tryptophan Hydroxylase 2 Antibody

Binding Specificity: pSer19

Purpose: TPH2 (phospho Ser19) Antibody

Specificity: Phospho-TPH2 (S19) Polyclonal Antibody detects endogenous levels of TPH2 protein only when phosphorylated at S19.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized phospho-peptide around the phosphorylation site of human TPH2 (phospho Ser19)

Isotype: IgG

Application Details

Application Notes: WB 1:500 - 1:2000. ELISA: 1:40000. Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Tryptophan Hydroxylase 2

Target: Tryptophan Hydroxylase 2 (TPH2)

Alternative Name: TPH2

Background:

Synonyms: TPH2, NTPH, Tryptophan 5-hydroxylase 2, Neuronal tryptophan hydroxylase, Tryptophan 5-monooxygenase 2

Background: This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression. [provided by RefSeq, Feb 2016],

Gene Name: TPH2

Protein Name: Tryptophan 5-hydroxylase 2

Gene ID: 121278

UniProt: Q8IWU9