TYRO3 antibody (pTyr685, pTyr753)

Catalog No. ABIN8125492

The Rabbit Polyclonal anti-TYRO3 antibody (ABIN8125492) specifically detects TYRO3 in WB, ELISA and IHC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for TYRO3 antibody (pTyr685, pTyr753) (ABIN8125492)

Target: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYRO3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-TYRO3 Antibody

Binding Specificity: pTyr685, pTyr753

Purpose: MER/TYRO3 (Phospho Tyr753/Tyr685) Antibody

Specificity: This antibody detects endogenous levels of MER/TYRO3 at Human:Y753/Y685,Mouse:Y748/Y675,Rat:Y748/Y675, It doesn't reacte with total protein.

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized phospho-peptide around the phosphorylation site of human MER/TYRO3 (Phospho-Tyr753/Tyr685)

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000,IHC 1:50-300, ELISA 2000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, containing 0.02 % sodium azide as Preservative and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for TYRO3

Target: TYRO3 (TYRO3 Protein Tyrosine Kinase (TYRO3))

Alternative Name: MER/TYRO3

Background:

Synonyms: MERTK MER

Background: This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008],

Gene Name: MERTK MER

Protein Name: c-mer proto-oncogene tyrosine kinase

Gene ID: 10461

UniProt: Q12866

Pathways: RTK Signaling