Tyrosinase-Related Protein 1 antibody (Cleaved-Asn126)

Catalog No. ABIN8125497

The Rabbit Polyclonal anti-Tyrosinase-Related Protein 1 antibody is suitable to detect Tyrosinase-Related Protein 1 in samples from Human, Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for Tyrosinase-Related Protein 1 antibody (Cleaved-Asn126) (ABIN8125497)

Target: Tyrosinase-Related Protein 1 (TYRP1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Tyrosinase-Related Protein 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Tyrosinase-Related Protein 1 Antibody

Binding Specificity: Cleaved-Asn126

Purpose: CATB (Cleaved-Asn126) Antibody

Specificity: This antibody detects endogenous levels of Human CATB (Cleaved-Asn126, protein was cleaved amino acid sequence between 126-127 )

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human CATB (Cleaved-Asn126)

Isotype: IgG

Application Details

Application Notes: WB 1:1000-2000 ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for Tyrosinase-Related Protein 1

Target: Tyrosinase-Related Protein 1 (TYRP1)

Alternative Name: CATB

Background:

Synonyms: Cathepsin B (EC 3.4.22.1, APP secretase, APPS, Cathepsin B1) [Cleaved into: Cathepsin B light chain, Cathepsin B heavy chain]

Background: catalytic activity:Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides.,function:Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.,similarity:Belongs to the peptidase C1 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Dimer of a heavy chain and a light chain cross-linked by a disulfide bond.,

Gene Name: CTSB CPSB

Protein Name: CATB (Cleaved-Asn126)

Gene ID: 1508

UniProt: P07858