TIE1 antibody (pTyr1117)

Catalog No. ABIN8125505

This Rabbit Polyclonal antibody specifically detects TIE1 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for TIE1 antibody (pTyr1117) (ABIN8125505)

Target: TIE1 (tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIE1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TIE1 Antibody

Binding Specificity: pTyr1117

Purpose: TIE1 (Phospho Tyr1117) Antibody

Specificity: This antibody detects endogenous levels of TIE1 (Phospho-Tyr1117) at Human, Mouse,Rat

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized peptide derived from human TIE1 (Phospho-Tyr1117)

Isotype: IgG

Application Details

Application Notes: WB 1:500-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for TIE1

Target: TIE1 (tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1))

Alternative Name: TIE1

Background:

Synonyms: Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1)

Background: This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],

Gene Name: TIE1 TIE

Protein Name: TIE1 (Phospho-Tyr1117)

Gene ID: 7075

UniProt: P35590

Pathways: RTK Signaling