TNK1 antibody (pTyr277)

Catalog No. ABIN8125506

The Rabbit Polyclonal anti-TNK1 antibody is suitable to detect TNK1 in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for TNK1 antibody (pTyr277) (ABIN8125506)

Target: TNK1 (Tyrosine Kinase, Non-Receptor, 1 (TNK1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNK1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TNK1 Antibody

Binding Specificity: pTyr277

Purpose: TNK1 (Phospho Tyr277) Antibody

Specificity: This antibody detects endogenous levels of Human TNK1 (phospho-Tyr277)

Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Immunogen: Synthesized phosho peptide around human TNK1 (Tyr277)

Isotype: IgG

Application Details

Application Notes: WB 1:1000-2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C/1 year

Expiry Date: 12 months

Target Details for TNK1

Target: TNK1 (Tyrosine Kinase, Non-Receptor, 1 (TNK1))

Alternative Name: TNK1

Background:

Synonyms: Non-receptor tyrosine-protein kinase TNK1 (EC 2.7.10.2) (CD38 negative kinase 1)

Background: The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],

Gene Name: TNK1

Protein Name: TNK1 (Tyr277)

Gene ID: 8711

UniProt: Q13470