Progesterone Receptor antibody (C-Term)

Catalog No. ABIN781660

This Mouse Monoclonal antibody specifically detects Progesterone Receptor in IHC (p) and IHC (fro). It exhibits reactivity toward Human, Rabbit and Chicken.

Quick Overview for Progesterone Receptor antibody (C-Term) (ABIN781660)

Target: Progesterone Receptor (PGR)

Reactivity: Human, Rabbit, Chicken

Host: Mouse

Clonality: Monoclonal

Conjugate: This Progesterone Receptor antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: PR-6A

Product Details anti-Progesterone Receptor Antibody

Binding Specificity: AA 922-933, C-Term

Specificity: This antibody PR-6A recognizes the Human Progesterone Receptor in the C-terminal ligand-binding domain. Therefore, it recognizes isoforms A and B. Antigen Distribution: Nuclear hormone receptor, widely expressed.

Cross-Reactivity (Details): Species reactivity (expected):Chicken and Rabbit.
Species reactivity (tested):Human, Pig.

Purification: Affinity Chromatography

Immunogen: Peptide A922-K933. Epitope: C-terminal region.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Restore by adding 0.5 mL distilled water

Concentration: 0.2 mg/mL

Buffer: Stock solution contains PBS, pH 7.2 with 5 mg/mL BSA as stabilizer and 0.01 % Kathon as a preservative.

Preservative: Kathon CG

Precaution of Use: This product contains Kathon CG a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Progesterone Receptor

Target: Progesterone Receptor (PGR)

Alternative Name: Progesterone Receptor

Background: The progesterone receptor is an intracellular steroid receptor that specifically binds progesterone. Expressed by a single gene (chromosome 11q22), it has two main forms, A and B, that differ in their molecular weight. It has been proposed that expression of PR determination indicates a responsive estrogen receptor (ER) pathway, and therefore, may predict likely response to endocrine therapy in human breast cancer. A number of studies have shown that PR determination provides supplementary information to ER, in predicting response to endocrine therapy as well as estimating survival. PR has proved superior to ER as a prognostic indicator in some studies. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.Synonyms: NR3C3, Nuclear Receptor Subfamily 3 Group C Member 3, PGR, PR

Gene ID: 5241

NCBI Accession: NP_000917

UniProt: P06401

Pathways: Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Smooth Muscle Cell Migration