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MCL-1 antibody (AA 121-139)
MCL1
Reactivity: Human
IHC (p)
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-MCL-1 Antibody
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Target
See all MCL-1 (MCL1) Antibodies
MCL-1 (MCL1)
(Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))
Binding Specificity
All epitopes for MCL-1 antibodies
AA 121-139
Reactivity
All reactivities for MCL-1 antibodies
Human
Host
All hosts for MCL-1 antibodies
Rabbit
Clonality
All clonalities for MCL-1 antibodies
Polyclonal
Conjugate
All conjugates for MCL-1 antibodies
This MCL-1 antibody is un-conjugated
Application
All applications for MCL-1 antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Specificity
This antibody reacts to Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1).
Purification
Immunoaffinity Chromatography
Immunogen
A synthetic peptide corresponding to aa 121-139 of human Mcl-1 Genename: MCL1
Isotype
IgG
Top Product
Discover our top product MCL1 Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
10 mM PBS, pH 7.4 containing 1 % BSA as stabilizer and 0,09 % sodium azide as preservative
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
Target Details for MCL-1
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Target
MCL-1 (MCL1)
(Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))
Alternative Name
MCL1 (MCL1 Products )
Synonyms
BCL2L3 antibody, EAT antibody, MCL1-ES antibody, MCL1L antibody, MCL1S antibody, Mcl-1 antibody, TM antibody, bcl2-L-3 antibody, mcl1/EAT antibody, AW556805 antibody, mcl-1 antibody, fb72f02 antibody, wu:fb70a08 antibody, wu:fb72f02 antibody, zfMLP1 antibody, zfMcl-1a antibody, zgc:109835 antibody, zgc:109763 antibody, E3 antibody, E3-2 antibody, RNE3 antibody, RNU107 antibody, SNORA63A antibody, elF-4AII antibody, MCL1, BCL2 family apoptosis regulator antibody, myeloid cell leukemia sequence 1 antibody, MCL1, BCL2 family apoptosis regulator a antibody, MCL1, BCL2 family apoptosis regulator b antibody, small nucleolar RNA, H/ACA box 63 antibody, MCL1 antibody, Mcl1 antibody, mcl1a antibody, mcl1b antibody, SNORA63 antibody
Background
Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis (5) and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.Synonyms: BCL2L3, Bcl-2-like protein 3, Bcl-2-related protein, EAT, Induced myeloid leukemia cell differentiation protein Mcl-1, mcl1/EAT, r004
Gene ID
4170
NCBI Accession
NP_001184249
Pathways
MAPK Signaling
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