Fascin 2 antibody (Internal Region)

Catalog No. ABIN783923

Product Details anti-Fascin 2 Antibody

Target: Fascin 2 (FSCN2)

Binding Specificity: Internal Region

Reactivity: Human, Mouse, Rat, Dog

Host: Goat

Clonality: Polyclonal

Conjugate: This Fascin 2 antibody is un-conjugated

Application: Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Sequence: CHHRGSNQLD TNR

Specificity: This antibody is expected to recognize both reported isoforms (NP_001070650.1 and NP_036550.1).

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat, Dog.
Species reactivity (tested):Human.

Purification: Affinity Chromatgraphy

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_001070650.1, NP_036550.1. Genename: FSCN2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Fascin 2

Target: Fascin 2 (FSCN2)

Alternative Name: Fascin-2 (FSCN2 Products)

Synonyms: fascin-2 antibody, A930022G03 antibody, C630046B20Rik antibody, ahl8 antibody, RFSN antibody, RP30 antibody, fascin actin-bundling protein 2, retinal antibody, fascin actin-bundling protein 1 antibody, fascin actin-bundling protein 2 antibody, FSCN2 antibody, FSCN1 antibody, Fscn2 antibody

Background: Fascin-2 Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Defects in FSCN2 are the cause of retinitis pigmentosa type 30 (RP30) [MIM:607921]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP30 inheritance is autosomal dominant.Synonyms: FSCN2, Retinal fascin

Gene ID: 25794

NCBI Accession: NP_001070650