ZEB2 antibody (C-Term)

Catalog No. ABIN784073

Product Details anti-ZEB2 Antibody

Target: ZEB2 (Zinc Finger E-Box Binding Homeobox 2 (ZEB2))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZEB2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to the C-term of ZEB2.

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogen: ZEB2 antibody was raised against an 18 amino acid synthetic near the carboxy terminus of Human ZEB2.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ZEB2

Target: ZEB2 (Zinc Finger E-Box Binding Homeobox 2 (ZEB2))

Alternative Name: ZFHX1B (ZEB2 Products)

Synonyms: ZFHX1B antibody, Zfhx1b antibody, HSPC082 antibody, SIP-1 antibody, SIP1 antibody, SMADIP1 antibody, 9130203F04Rik antibody, D130016B08Rik antibody, Zfx1b antibody, Zfxh1b antibody, mKIAA0569 antibody, XSip1 antibody, sip1 antibody, zfhx1b antibody, si:dkey-52o2.2 antibody, sip1a antibody, wu:fc92g08 antibody, sip1b antibody, zinc finger E-box binding homeobox 2 antibody, zinc finger E-box binding homeobox 2 S homeolog antibody, zinc finger homeobox protein antibody, zinc finger E-box binding homeobox 2a antibody, zinc finger E-box binding homeobox 2b antibody, ZEB2 antibody, Zeb2 antibody, zeb2.S antibody, zeb2 antibody, zeb2a antibody, zeb2b antibody

Background: ZEB2, initially identified as Smad interacting-protein 1, is normally located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Like the homologous ZEB1, ZEB2 inhibits the transcription of the E-cadherin gene and induces epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing, in vitro. ZEB2 can also protect cells from DNA damage-induced apoptosis, suggesting that its expression may contribute to tumor progression. Recent evidence has shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, indicating that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Hirschsprung disease/Mowat-Wilson syndrome.Synonyms: KIAA0569, SIP1, SMADIP1, Smad-interacting protein 1, ZEB2, ZFX1B, Zinc finger E-box-binding homeobox 2, Zinc finger homeobox protein 1b

Gene ID: 9839

NCBI Accession: NP_001165124

Pathways: Tube Formation