Desmoglein 1 antibody

Catalog No. ABIN784305

Product Details anti-Desmoglein 1 Antibody

Target: Desmoglein 1 (DSG1)

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This Desmoglein 1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to the internal region of DSG1.

Purification: Immunoaffinity chromatography

Immunogen: Synthetic peptide - KLH conjugated Remarks: Family: Cadherin Subfamily: not assigned-Cadherin

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0,5 mg/mL

Buffer: Tris saline buffer, pH 7.3 containing 0.5 % BSA as stabilizer and 0.02 % sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Desmoglein 1

Target: Desmoglein 1 (DSG1)

Alternative Name: Desmoglein-1 (DSG1 Products)

Synonyms: CDHF4 antibody, DG1 antibody, DSG antibody, PPKS1 antibody, SPPK1 antibody, DSG-1 antibody, DSG1 antibody, Dsg1b antibody, Dsg1c antibody, desmoglein 1 antibody, desmoglein 4 antibody, DSG1 antibody, DSG4 antibody, Dsg1 antibody

Background: Desmosomes are a type of intercellular junction between epithelial, myocardial, and certain other cell types. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein isoforms have been identified: DSG1, DSG2 and DSG3, all members of the cadherin cell adhesion molecule family. DSG1 has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus foliaceus.Synonyms: CDHF4, Cadherin family member 4, DG1, DGI, DSG1, Desmosomal glycoprotein 1, Pemphigus foliaceus antigen

Gene ID: 1828

NCBI Accession: NP_001933

Pathways: Cell-Cell Junction Organization