UCHL1 antibody (C-Term)

Catalog No. ABIN784576

This Rabbit Polyclonal antibody specifically detects UCHL1 in WB, IHC (p) and EIA. It exhibits reactivity toward Human, Rat and Mouse.

Quick Overview for UCHL1 antibody (C-Term) (ABIN784576)

Target: UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UCHL1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-UCHL1 Antibody

Binding Specificity: C-Term

Specificity: This antibody detects endogenous levels of total PGP9.5 protein.

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogen: Synthetic peptide - KLH conjugated Remarks: Antigen Modification: C-Terminus

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM Sodium Chloride, 0.02 % Sodium Azide and 50 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C. Avoid freeze-thaw cycles.

Target Details for UCHL1

Target: UCHL1 (Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase) (UCHL1))

Alternative Name: UCHL1 / PGP9.5

Background: UCHL1 is a member of family of proteins that hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. The expression of UCHL1 is highly specific to neurons and to cell of the diffuse neuroendocrine system and their tumors. UCHL1 exhibits both and hydrolase and a ligase activity. The S18Y variant of UCHL1, that has reduced ligase activity, has been linked to susceptibility for Parkinson's disease.Synonyms: Neuron cytoplasmic protein 9.5, PGP 9.5, UCH-L1, Ubiquitin carboxyl-terminal hydrolase isozyme L1, Ubiquitin thioesterase L1

Gene ID: 7345

NCBI Accession: NP_004172

Pathways: Feeding Behaviour