PDGFRA antibody (AA 1035-1053)

Catalog No. ABIN784591

This Rabbit Polyclonal antibody specifically detects PDGFRA in WB, IHC (p) and IP. It exhibits reactivity toward Human, Mouse, Rat, Chicken and Xenopus laevis.

Quick Overview for PDGFRA antibody (AA 1035-1053) (ABIN784591)

Target: PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))

Reactivity: Human, Mouse, Rat, Chicken, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDGFRA antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Product Details anti-PDGFRA Antibody

Binding Specificity: AA 1035-1053

Sequence: C-GKRNRHSSQT SEESAIETG Remarks: Antigen Modificati on: Amino acids 1035-1053

Specificity: Recognizes Human PDGF Receptor Type A, doublet, Mr 150/170 kDa.

Cross-Reactivity (Details): Species reactivity (expected):Chicken, Frog, Mouse, Rat, Zebrafish.
Species reactivity (tested):Human.

Purification: Immunoaffinity Chromatography

Immunogen: Synthetic peptide KLH-conjugated corresponding to amino acids 1035-1053 of Human PDGF.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.2 M Tris-Glycine, pH 7.4 containing 0.12 M Sodium Chloride and 0.05 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid freeze-thaw cycles.

Target Details for PDGFRA

Target: PDGFRA (Platelet Derived Growth Factor Receptor alpha (PDGFRA))

Alternative Name: CD140a / PDGFRA

Background: Platelet-derived Growth Factor Receptor Alpha (PDGFR alpha), a member of the a PDGF Receptor tyrosine kinase family, is a mediator of the biological actions of platelet-derived growth factor (PDGF). PDGF binding to PDGF receptors result in stimulation of cell growth, chemotaxis, and cell shape changes. Unlike PDGFR beta, PDGFR alpha can bind to both PDGF subunits. PDGFR alpha has been implicated in the development of spina bifida. In various mouse models, deregulated PDGFR alpha expression was found to result in congenital neural tube defects. In humans, various PDGFRA promoter haplotypes have been associated with neural tube defects.Synonyms: Alpha-type platelet-derived growth factor receptor, CD140 antigen-like family member A, PDGF Receptor alpha, PDGF-R-alpha

Gene ID: 5156

NCBI Accession: NP_006197

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Platelet-derived growth Factor Receptor Signaling