Estrogen Receptor alpha antibody (C-Term)

Catalog No. ABIN870443

Product Details anti-Estrogen Receptor alpha Antibody

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Binding Specificity: AA 580-594, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Estrogen Receptor alpha antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purpose: Anti-ER (Estrogen Receptor)

Specificity: ER (Estrogen Receptor)

Immunogen: Peptide derived from C-terminal sequence of human estrogen receptor alpha. Antibody recognizes the epitope between Gln580 - Thr594.

Clone: S21-V

Isotype: IgG

Application Details

Application Notes: 1:100 - 200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 20 mM Tris-HCI, pH 8.0, Stabilizer: 20 mg/mL BSA, Preservative: 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: +2 °C to +8 °C

Target Details for Estrogen Receptor alpha

Target: Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))

Alternative Name: Estrogen Receptor (ESR1 Products)

Background: Estrogen Receptor- α antibody stains nuclei of breast epithelial cells and some carcinomas, as well as endometrial epithelia and myometrium. By binding to the DNA, estrogen receptor-α regulates positively or negatively the gene expression. ER plays an important role in regulation of mammary gland growth and differentiation. Its overexpression can be found in more than 70 % of breast cancer.

UniProt: P03372

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly