LCK antibody (pTyr505) (AbBy Fluor® 350)

Catalog No. ABIN879781

This Rabbit Polyclonal antibody specifically detects LCK in IF (cc) and IF (p). It exhibits reactivity toward Human.

Quick Overview for LCK antibody (pTyr505) (AbBy Fluor® 350) (ABIN879781)

Target: LCK (Lymphocyte-Specific Protein tyrosine Kinase (LCK))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LCK antibody is conjugated to AbBy Fluor® 350

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-LCK Antibody (AbBy Fluor® 350)

Binding Specificity: pTyr505

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human Lck around the phosphorylation site of Tyr505

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for LCK

Target: LCK (Lymphocyte-Specific Protein tyrosine Kinase (LCK))

Alternative Name: LCK

Background:

Synonyms: LCK phospho Y505, LCK phospho Tyr505, p-LCK Tyr505, p56-LCK, Lymphocyte cell-specic protein-tyrosine kinase, LSK, T cell-specic protein-tyrosine kinase, Lck p56, LSK, Lymphocyte Specic Protein Tyrosine Kinase, Membrane associated protein tyrosine kinase, Oncogene lck, P56 LCK, p56LSTRA protein tyrosine kinase, p56lck, pp58 lck, pp58lck, Proto oncogene tyrosine protein kinase LCK, Protooncogene tyrosine protein kinase LCK, T cell specic protein tyrosine kinase, T lymphocyte specic protein tyrosine kinase p56lck, YT 16, YT16, LCK_HUMAN.

Background: This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008].

Gene ID: 3932

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling