APH1A antibody (AA 71-170) (AbBy Fluor® 488)

Catalog No. ABIN883020

This anti-APH1A antibody is a Rabbit Polyclonal antibody detecting APH1A in WB, FACS, IF (cc) and IF (p). Suitable for Human, Mouse and Rat.

Quick Overview for APH1A antibody (AA 71-170) (AbBy Fluor® 488) (ABIN883020)

Target: APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APH1A antibody is conjugated to AbBy Fluor® 488

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-APH1A Antibody (AbBy Fluor® 488)

Binding Specificity: AA 71-170

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human APH1a

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for APH1A

Target: APH1A (Anterior Pharynx Defective 1 Homolog A (C. Elegans) (APH1A))

Alternative Name: APH1a

Background:

Synonyms: APH-1, APH-1A, CGI-78, 6530402N02Rik, Gamma-secretase subunit APH-1A, Aph-1alpha, Presenilin-stabilization factor, APH1A, PSF, UNQ579/PRO1141

Background: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.

Gene ID: 51107

UniProt: Q96BI3

Pathways: Notch Signaling, Neurotrophin Signaling Pathway