BRIP1 antibody (AbBy Fluor® 488)

Catalog No. ABIN884392

This Rabbit Polyclonal antibody specifically detects BRIP1 in IF (p). It exhibits reactivity toward Human, Mouse, Rat, Chicken, Cow, Dog, Horse and Pig.

Quick Overview for BRIP1 antibody (AbBy Fluor® 488) (ABIN884392)

Target: BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1))

Reactivity: Human, Mouse, Rat, Chicken, Cow, Dog, Horse, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRIP1 antibody is conjugated to AbBy Fluor® 488

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-BRIP1 Antibody (AbBy Fluor® 488)

Specificity: Excitation / Emission Wavelengths: 499nm/519nm

Purification: Antibodies are purified by protein A and peptide affinity chromatography.

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human BACH1
Please inquire for sequence information.

Isotype: IgG

Application Details

Application Notes: IF(IHC-P)(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Aqueous buffered solution containing 100 µg/mL BSA, 50 % glycerol and 0.09 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for BRIP1

Target: BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1 (BRIP1))

Alternative Name: BACH1/BRIP1

Background: BACH1 is a member of the DEAH helicase family that interacts with BRCA1, in vivo. BACH1 is a DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. BACH1 acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination, and is involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. The BACH1/BRCA1 complex formation contributes to a key function of BRCA1. Therefore, it is likely that BACH1 is a target of germline cancer-inducing mutations.
Synonym: BACH 1, BRIP1, BACH-1, BRAC 1 Associated C Terminal Helicase 1, BRCA 1 Interacting Protein 1, BRCA1 binding helicase like protein BACH1, BRCA1 interacting protein C terminal helicase 1, BRIP 1, BRIP-1, FANCJ, ATP dependent RNA helicase BRIP1, Fanconi anemia group J protein, FLJ90232, MGC126521, MGC126523, OF antibody Protein FACJ.

Molecular Weight: 130kDa

Gene ID: 571

Pathways: DNA Damage Repair