COMMD1 antibody (AA 95-190) (Alexa Fluor 488)

Catalog No. ABIN891768

Product Details anti-COMMD1 Antibody (Alexa Fluor 488)

Target: COMMD1 (Copper Metabolism (Murr1) Domain Containing 1 (COMMD1))

Binding Specificity: AA 95-190

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COMMD1 antibody is conjugated to Alexa Fluor 488

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Cow,Sheep,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human COMMD1/MURR1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for COMMD1

Target: COMMD1 (Copper Metabolism (Murr1) Domain Containing 1 (COMMD1))

Alternative Name: COMMD1 (COMMD1 Products)

Synonyms: C2orf5 antibody, MURR1 antibody, murr1 antibody, commd1 antibody, si:ch211-213b8.2 antibody, DDBDRAFT_0184206 antibody, DDBDRAFT_0266452 antibody, DDB_0184206 antibody, DDB_0266452 antibody, COMMD1 antibody, MGC114682 antibody, AI256843 antibody, Murr1 antibody, U2/Mu antibody, copper metabolism domain containing 1 antibody, copper metabolism (Murr1) domain containing 1 antibody, COMM domain-containing protein 1 antibody, copper metabolism domain containing 1 L homeolog antibody, COMM domain containing 1 antibody, COMMD1 antibody, commd1 antibody, comd1 antibody, Commd1 antibody, commd1.L antibody

Background:

Synonyms: C2orf5, COMD1, COMD1_HUMAN, COMM domain-containing protein 1, COMMD1, copper metabolism domain containing 1, MGC27155, MURR1, Protein Murr1.

Background: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.Tissue specificity:Ubiquitous. Highest expression in the liver, with lower expression in brain, lung, placenta, pancreas, small intestine, heart, skeletal muscle, kidney and placenta.

Gene ID: 150684

Pathways: Transition Metal Ion Homeostasis