e6/ ITGB4BP (AA 141-245) antibody (Alexa Fluor 555)

Catalog No. ABIN895129

Product Details

Target: e6/ ITGB4BP

Binding Specificity: AA 141-245

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Alexa Fluor 555

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human eIF6

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: e6/ ITGB4BP

Alternative Name: e6/ITGB4BP

Background:

Synonyms: b2gcn, B2GCN homolog, B4 integrin interactor, Binding protein of beta-4 integrin, CAB, e-6, E3A, E6, Eukaryotic translation initiation factor 3A, Eukaryotic translation initiation factor 6, 6_HUMAN, ITGB4BP, OK/SW-cl.27, p27 beta 4 integrin binding protein, p27BBP, p27BBP, RP4-614O4.1.

Background: Hemidesmosomes are structures which link the basal lamina to the intermediate filament cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (ITGB4), a protein containing two fibronectin type III domains. The protein encoded by Intergrin beta 4 binding protein binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the cytoplasm, can function as a translation initiation factor and prevent the association of the 40S and 60S ribosomal subunits. Multiple transcript variants encoding several different isoforms have been found for this gene.

Gene ID: 3692