INSRR antibody (PE)

Catalog No. ABIN902841

The PE-conjugated Rabbit Polyclonal anti-INSRR antibody (ABIN902841) specifically detects INSRR in IF (p). The antibody is reactive with Human, Mouse, Rat, Cow, Dog and Pig samples.

Quick Overview for INSRR antibody (PE) (ABIN902841)

Target: INSRR (Insulin Receptor-Related Receptor (INSRR))

Reactivity: Human, Mouse, Rat, Cow, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This INSRR antibody is conjugated to PE

Application: Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-INSRR Antibody (PE)

Specificity: Excitation / Emission Wavelengths: 565nm/578nm

Cross-Reactivity: Rat (Rattus), Dog (Canine), Pig (Porcine), Cow (Bovine)

Purification: purified by Protein A

Immunogen: KLH conjugated synthetic peptide derived from human Insulin receptor-related protein beta chain

Isotype: IgG

Application Details

Comment:

Excitation / Emission wavelength: 496nm / 578nm

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 µg/µL

Buffer: Aqueous buffered solution containing 100 µg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 4 °C for 12 months

Expiry Date: 12 months

Target Details for INSRR

Target: INSRR (Insulin Receptor-Related Receptor (INSRR))

Alternative Name: INSRR

Background: The insulin receptor related receptor (IRR) is a heterotetrameric transmembrane receptor composed of two alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. Member of the insulin RTK family, IRR shares high homology with the insulin (IR) and the insulin-like growth factor-1 receptor (IGF-1R), but doesnﾒt bind any of IR and IGF-1R known ligands. In contrast to the widespread patterns of expression to IR and IGF-1R, IRR demonstrates a very restricted cellular distribution in a subset of tissues of neuronal origin and its biological functions are still unknown.

Molecular Weight: 144kDa

Gene ID: 3645

Pathways: RTK Signaling