ITGAV/ITGB6 antibody (Alexa Fluor 488)

Catalog No. ABIN902934

Product Details anti-ITGAV/ITGB6 Antibody (Alexa Fluor 488)

Target: ITGAV/ITGB6 (Integrin AlphaV Beta6 (ITGAV/ITGB6))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ITGAV/ITGB6 antibody is conjugated to Alexa Fluor 488

Application: Flow Cytometry (FACS), Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Integrin Alpha V + Beta 6

Isotype: IgG

Application Details

Application Notes: FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ITGAV/ITGB6

Target: ITGAV/ITGB6 (Integrin AlphaV Beta6 (ITGAV/ITGB6))

Alternative Name: Integrin Alpha V + Beta 6 (ITGAV/ITGB6 Products)

Background:

Synonyms: CD51, Integrin alpha-V light chain, integrin, alpha V vitronectin receptor, alpha polypeptide, antigen CD51, Integrin, alpha V, Integrin, beta 6, ITAV_HUMAN, ITGAV, ITGB6, Vitronectin receptor subunit alpha.

Background: Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells. Integrin alpha-v beta-6 is upregulated in cancers and during tissue remodelling but is absent from resting adult tissues. Integrin alpha-v beta-6 promotes invasion and correlates with poor survival and therefore makes a promising therapeutic target.

Gene ID: 36853694