Kininogen-1 Heavy Chain (AA 281-356) antibody (Alexa Fluor 350)

Catalog No. ABIN905010

Product Details

Target: Kininogen-1 Heavy Chain

Binding Specificity: AA 281-356

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Alexa Fluor 350

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Kininogen-1 heavy chain

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Kininogen-1 Heavy Chain

Synonyms: BDK antibody, BK antibody, KNG antibody, kininogen 1 antibody, KNG1 antibody

Background:

Synonyms: BDK, Kininogen 1, Kininogen1, Kininogen-1, KNG1, LMW, Low molecular weight growth promoting factor, Low molecular weight kininogen, Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, High molecular weight kininogen, HMWK, HMWK heavy chain, Ile-Ser-Bradykinin, Kallidin I, Kallidin II, Kininogen 1, Kininogen 1 heavy chain, KNG, KNG1_HUMAN, Williams-Fitzgerald-Flaujeac factor.

Background: This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009].

Gene ID: 3827