NCOR1 antibody (AA 2301-2400) (Alexa Fluor 647)

Catalog No. ABIN907775

Product Details anti-NCOR1 Antibody (Alexa Fluor 647)

Target: NCOR1 (Nuclear Receptor Co-Repressor 1 (NCOR1))

Binding Specificity: AA 2301-2400

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOR1 antibody is conjugated to Alexa Fluor 647

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Predicted Reactivity: Human,Mouse,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NC0R1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NCOR1

Target: NCOR1 (Nuclear Receptor Co-Repressor 1 (NCOR1))

Alternative Name: NCoR1 (NCOR1 Products)

Synonyms: ncor antibody, zgc:56355 antibody, 5730405M06Rik antibody, A230020K14Rik antibody, N-CoR antibody, RIP13 antibody, Rxrip13 antibody, mKIAA1047 antibody, N-CoR1 antibody, TRAC1 antibody, hN-CoR antibody, nuclear receptor corepressor 1 antibody, nuclear receptor co-repressor 1 antibody, nuclear receptor corepressor 1 pseudogene antibody, nuclear receptor corepressor 1 S homeolog antibody, ncor1 antibody, NCOR1 antibody, CpipJ_CPIJ002507 antibody, LOC100343278 antibody, Ncor1 antibody, ncor1.S antibody

Background:

Synonyms: RIP13, Rxrip13, hCIT529I10, hN CoR, hNCoR, KIAA1047, MGC104216, N CoR, N Cor/SMRT corepressor Rip13, N CoR1, NCOR 1, NCoR, NCOR1, Nuclear receptor co repressor 1, Nuclear receptor corepressor 1, Retinoid X receptor interacting protein 13, thyroid hormone and retinoic acid receptor associated corepressor 1, thyroid hormone- and retinoic acid receptor-associated corepressor 1, TRAC 1, TRAC1, Nuclear Receptor Corepressor NCoR, NCOR1_MOUSE.

Background: Nuclear co-repressor 2 (N-CoR2) gene (NCOR2, previously called silencing mediator for retinoid and thyroid hormone receptor SMRT) is recruited to nuclear and non-nuclear receptors in a large repressing complex containing also N-CoR1, mSin3 and HDACs. This large complex represses transcription in absence of ligand. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Tissue specificity: Ubiquitous. It is belongs to the N-CoR nuclear receptor corepressors family.

Gene ID: 9611

Pathways: Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process