Pp1a/Pp2ca/Ppp1ca (AA 281-382) antibody (Alexa Fluor 350)

Catalog No. ABIN911758

Product Details

Target: Pp1a/Pp2ca/Ppp1ca

Binding Specificity: AA 281-382

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Alexa Fluor 350

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PPP1CA

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Pp1a/Pp2ca/Ppp1ca

Background:

Synonyms: PP 1A, PP1A, PP2C ALPHA, PP2CA, PPP1CA, Protein Phosphatase 2C Alpha Isoform, Serine threonine protein phosphatase PP1 alpha catalytic subunit, EC 3.1.3.16, MGC15877, MGC1674, MGC9201.

Background: PPP1A is a serine/threonine protein phosphatase catalytic subunit that is essential for regulating cellular stress responses in eukaryotes. It binds to magnesium or manganese ions and exists as a monomer. It is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. PPP1A is involved in the regulation long term synaptic plasticity and may play an important role in dephosphorylating substrates such as Ca2+/calmodulin dependent protein kinase II.

Gene ID: 5499

UniProt: P62136