TARDBP antibody (AA 21-120) (AbBy Fluor® 647)

Catalog No. ABIN917286

This anti-TARDBP antibody is a Rabbit Polyclonal antibody detecting TARDBP in WB, IF (cc) and IF (p). Suitable for Rat.

Quick Overview for TARDBP antibody (AA 21-120) (AbBy Fluor® 647) (ABIN917286)

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TARDBP antibody is conjugated to AbBy Fluor® 647

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-TARDBP Antibody (AbBy Fluor® 647)

Binding Specificity: AA 21-120

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Cow,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TDP-43

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for TARDBP

Target: TARDBP (TAR DNA Binding Protein (TARDBP))

Alternative Name: TARDBP

Background:

Synonyms: ALS10, TDP-43, TAR DNA-binding protein 43, TARDBP, TDP43

Background: DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.

Gene ID: 23435

UniProt: Q13148

Pathways: Positive Regulation of Peptide Hormone Secretion