DR4 antibody (AA 401-468) (Alexa Fluor 350)

Catalog No. ABIN918466

Product Details anti-DR4 Antibody (Alexa Fluor 350)

Target: DR4 (Drought-Repressed 4 Protein (DR4))

Binding Specificity: AA 401-468

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DR4 antibody is conjugated to Alexa Fluor 350

Application: Western Blotting (WB)

Cross-Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DR4

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DR4

Target: DR4 (Drought-Repressed 4 Protein (DR4))

Alternative Name: DR4 (DR4 Products)

Synonyms: APO2 antibody, CD261 antibody, DR4 antibody, TRAILR-1 antibody, TRAILR1 antibody, TNF receptor superfamily member 10a antibody, TNFRSF10A antibody

Background:

Synonyms: DR4, APO2, CD261, TRAILR1, TRAILR-1, Tumor necrosis factor receptor superfamily member 10A, Death receptor 4, TNF-related apoptosis-inducing ligand receptor 1, TRAIL receptor 1, TRAIL-R1, TNFRSF10A

Background: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.

Gene ID: 8797

UniProt: O00220

Pathways: Apoptosis, Positive Regulation of Endopeptidase Activity