TLR4 antibody (N-Term)

Catalog No. ABIN920639

The Rabbit Polyclonal anti-TLR4 antibody is suitable to detect TLR4 in samples from Human. It has been validated for WB and ICC.

Quick Overview for TLR4 antibody (N-Term) (ABIN920639)

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TLR4 antibody is un-conjugated

Application: Western Blotting (WB), Immunocytochemistry (ICC)

Product Details anti-TLR4 Antibody

Binding Specificity: N-Term

Characteristics: Positive Control: Located in the membrane and highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells.

Purification: Antigen Immunoaffinity purified

Immunogen: Rabbit polyclonal TLR4 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of TLR4.

Isotype: IgG

Application Details

Application Notes: Western blot: use at 2-5 µg/mL

Restrictions: For Research Use only

Handling

Buffer: Phosphate buffered saline with 0.02% sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for TLR4

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Background: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Studies with TLR4 deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram- negative sepsis. Synonyms:

Molecular Weight: 95 kDa

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins