Factor XI antibody (C-Term)

Catalog No. ABIN926655

Product Details anti-Factor XI Antibody

Target: Factor XI (F11) (Coagulation Factor XI (F11))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Factor XI antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Immunogen: F11 antibody was raised in rabbit using the C terminal of F11 as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

F11 Blocking Peptide, catalog no. 33R-7950, is also available for use as a blocking control in assays to test for specificity of this F11 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for Factor XI

Target: Factor XI (F11) (Coagulation Factor XI (F11))

Alternative Name: F11 (F11 Products)

Synonyms: FXI antibody, 1600027G01Rik antibody, AI503996 antibody, Cf11 antibody, LRRGT00086 antibody, coagulation factor XI antibody, F11 antibody, CpipJ_CPIJ000593 antibody, CpipJ_CPIJ001060 antibody, CpipJ_CPIJ002752 antibody, CpipJ_CPIJ003631 antibody, CpipJ_CPIJ004041 antibody, CpipJ_CPIJ004093 antibody

Background: This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality. Synonyms: Polyclonal F11 antibody, Anti-F11 antibody, coagulation factor XI antibody, FXI antibody, MGC141891 antibody.