AIF antibody (Middle Region)
Quick Overview for AIF antibody (Middle Region) (ABIN926871)
Target
See all AIF (AIFM1) AntibodiesReactivity
Host
Clonality
Conjugate
Application
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Binding Specificity
- Middle Region
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Cross-Reactivity
- Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine), Zebrafish (Brachydanio rerio), Chicken
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Purification
- Purified
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Immunogen
- AIFM1 antibody was raised in rabbit using the middle region of AIFM1 as the immunogen
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Application Notes
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WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator. -
Comment
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AIFM1 Blocking Peptide, , is also available for use as a blocking control in assays to test for specificity of this AIFM1 antibody
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Concentration
- Lot specific
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Buffer
- Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.
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Handling Advice
- Avoid repeated freeze/thaw cycles.
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Storage
- 4 °C/-20 °C
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Storage Comment
- Store at 4 °C, following reconstitution, aliquot and store at -20 °C.
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- AIF (AIFM1) (Apoptosis-Inducing Factor, Mitochondrion-Associated, 1 (AIFM1))
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Alternative Name
- AIFM1
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Background
- AIFM1 is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this protein induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Several alternative transcripts encoding different isoforms have been identified for this gene. Synonyms: Polyclonal AIFM1 antibody, Anti-AIFM1 antibody, apoptosis-inducing factor, mitochondrion-associated, 1 antibody, AIF antibody, MGC111425 antibody, PDCD8 antibody.
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Pathways
- Apoptosis, Positive Regulation of Endopeptidase Activity, Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Warburg Effect
Target
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