MDC1 antibody (C-Term)

Catalog No. ABIN927646

This Rabbit Polyclonal antibody specifically detects MDC1 in WB. It exhibits reactivity toward Human.

Quick Overview for MDC1 antibody (C-Term) (ABIN927646)

Target: MDC1 (Mdc1 (MDC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MDC1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-MDC1 Antibody

Binding Specificity: C-Term

Purification: Purified

Immunogen: MDC1 antibody was raised in rabbit using the C terminal of MDC1 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for MDC1

Target: MDC1 (Mdc1 (MDC1))

Alternative Name: MDC1

Background: The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. Synonyms: Polyclonal MDC1 antibody, Anti-MDC1 antibody, mediator of DNA-damage checkpoint 1 antibody, DKFZp781A0122 antibody, KIAA0170 antibody, MGC166888 antibody, NFBD1 antibody.