TANK antibody (N-Term)

Catalog No. ABIN927715

This Rabbit Polyclonal antibody specifically detects TANK in WB. It exhibits reactivity toward Human, Mouse, Rat, Cow, Dog and Chicken.

Quick Overview for TANK antibody (N-Term) (ABIN927715)

Target: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Reactivity: Human, Mouse, Rat, Cow, Dog, Chicken

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TANK antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TANK Antibody

Binding Specificity: N-Term

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Cow (Bovine), Chicken, Dog (Canine)

Purification: Purified

Immunogen: TANK antibody was raised in rabbit using the N terminal of TANK as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

TANK Blocking Peptide, (ABIN937413), is also available for use as a blocking control in assays to test for specificity of this TANK antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for TANK

Target: TANK (TRAF Family Member-Associated NFKB Activator (TANK))

Alternative Name: TANK

Background: The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. TANK is found in the cytoplasm and can bind to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering the TRAFs in a latent state in the cytoplasm. For example, TANK can block TRAF2 binding to LMP1, the Epstein-Barr virus transforming protein, and inhibit LMP1-mediated NF-kappa-B activation.The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. Synonyms: Polyclonal TANK antibody, Anti-TANK antibody, TRAF family member-associated NFKB activator antibody, I-TRAF antibody, TRAF2 antibody.

Pathways: p53 Signaling, TLR Signaling, Activation of Innate immune Response