CTSC antibody (Middle Region)

Catalog No. ABIN929442

Product Details anti-CTSC Antibody

Target: CTSC (Cathepsin C (CTSC))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTSC antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Immunogen: CTSC antibody was raised in rabbit using the middle region of CTSC as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

CTSC Blocking Peptide, catalog no. 33R-10021, is also available for use as a blocking control in assays to test for specificity of this CTSC antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for CTSC

Target: CTSC (Cathepsin C (CTSC))

Alternative Name: CTSC (CTSC Products)

Synonyms: CPPI antibody, DPP-I antibody, DPP1 antibody, DPPI antibody, HMS antibody, JP antibody, JPD antibody, PALS antibody, PDON1 antibody, PLS antibody, MGC69126 antibody, MGC107782 antibody, AI047818 antibody, CATC antibody, cb912 antibody, ik:tdsubc_1h2 antibody, sb:cb146 antibody, wu:fb34g12 antibody, wu:fj58d01 antibody, cathepsin C antibody, cathepsin C L homeolog antibody, cathepsin CPC1 antibody, CTSC antibody, ctsc.L antibody, ctsc antibody, TP03_0357 antibody, CMU_003360 antibody, CPC1 antibody, NAEGRDRAFT_80477 antibody, NAEGRDRAFT_37577 antibody, Ctsc antibody, Smp_183330 antibody

Background: CTSC is a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in CTSC have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Synonyms: Polyclonal CTSC antibody, Anti-CTSC antibody, cathepsin C antibody, CPPI antibody, DPP1 antibody, DPPI antibody, HMS antibody, JP antibody, JPD antibody, PALS antibody, PLS antibody.