Calcineurin B antibody
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- Target See all Calcineurin B (CAN) Antibodies
- Calcineurin B (CAN)
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Reactivity
- Human
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Host
- Mouse
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Clonality
- Monoclonal
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Conjugate
- This Calcineurin B antibody is un-conjugated
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Application
- Western Blotting (WB)
- Cross-Reactivity
- Human, Mouse (Murine), Rat (Rattus)
- Sterility
- Filtered
- Immunogen
- Calcineurin B antibody was raised in mouse using E. coli-derived recombinant human calcineurin B as the immunogen.
- Clone
- 323417
- Isotype
- IgG2a
- Top Product
- Discover our top product CAN Primary Antibody
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- Application Notes
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WB: 0.5 µg/mL
Optimal conditions should be determined by the investigator. - Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with sterile PBS.
- Concentration
- Lot specific
- Buffer
- Lyophilized from a 0.2 µm filtered solution in PBS with 5 % trehalose.
- Handling Advice
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Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use. - Storage
- 4 °C/-20 °C
- Storage Comment
- Store at -20 °C until reconstitution. Following reconstitution product may be stored at 4 °C in the short term. For long term storage aliquot and freeze at -20 °C.
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- Target
- Calcineurin B (CAN)
- Alternative Name
- Calcineurin B (CAN Products)
- Synonyms
- PPP3RL antibody, BcDNA:RH11383 antibody, CG4209 antibody, CNB antibody, Can antibody, CnB antibody, Dmel\\CG4209 antibody, canB-4F antibody, dCnB1 antibody, Cnb antibody, Cblp antibody, CaNB2 antibody, protein phosphatase 3 regulatory subunit B, beta antibody, Calcineurin B antibody, calcineurin B antibody, protein phosphatase 3, regulatory subunit B, beta antibody, protein phosphatase 3 regulatory subunit B, alpha antibody, protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) antibody, PPP3R2 antibody, CanB antibody, Cnb antibody, Ppp3r2 antibody, PPP3R1 antibody
- Background
- Calcineurin (CN) is a protein phosphatase also known as protein phosphatase 3, PPP3CA, and formerly known as protein phosphatase 2B (PP2B). It activates the T cells of the immune system and can be blocked by drugs. Calcineurin activates NFATc (Nuclear Factor of Activated T cell, cytoplasmic), a transcription factor, by dephosphorylating it. The activated NFATc is then translocated into the nucleus, where it upregulates the expression of interleukin 2 (IL-2), which, in turn, stimulates the growth and differentiation of T cell response. Calcineurin is the target of a class of drugs called calcineurin inhibitors, which includes ciclosporin, pimecrolimus and tacrolimus. Synonyms: Monoclonal Calcineurin B antibody, Anti-Calcineurin B antibody.
- Pathways
- Cellular Glucan Metabolic Process, VEGF Signaling
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