MICA antibody (MHC Class I Polypeptide-Related Sequence A)

Details for Product anti-MICA Antibody No. ABIN94331
Antigen
Reactivity
Human
142
21
15
14
14
7
4
1
Host
Mouse
87
53
Clonality (Clone)
Monoclonal ()
Conjugate
This MICA antibody is un-conjugated
11
7
6
2
2
2
2
2
2
2
1
1
Application
Flow Cytometry (FACS)
101
61
52
37
33
16
14
11
11
9
7
6
5
5
1
1
1
1
Options
Immunogen Leukocytes of a patient suffering with LGL type leukemia.
Clone MEM-81
Isotype IgG1
Specificity The antibody MEM-81 reacts with human classical MHC Class I molecules in native cell-surface forms. MHC Class I molecules (MHC Class Ia) are expressed on the surface of human nucleated cell types.
Cross-Reactivity (Details) Human
Purification Purified by protein-A affinity chromatography
Purity > 95 % (by SDS-PAGE)
Antigen
Alternative Name HLA-Class I (MICA Antibody Abstract)
Background HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumour defence. Human HLA-class I antigens are represented by HLA-A, HLA-B and HLA-C molecules.
Pathways Activation of Innate immune Response, Transition Metal Ion Homeostasis, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Do not freeze.
Storage 4 °C
Storage Comment Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.