C9 antibody

Catalog No. ABIN951643

Product Details anti-C9 Antibody

Target: C9 (Complement Component C9 (C9))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This C9 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Recognizes Complement C9

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Ammonium Sulfate Precipitation

Immunogen: Protein purified from Human plasma.

Clone: 6-40E-010

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: HEPES with 0.15 M NaCl, 0.01 % BSA, 0.03 % Sdium Azide and 50 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for C9

Target: C9 (Complement Component C9 (C9))

Alternative Name: Complement C9 (C9 Products)

Synonyms: LOC100037951 antibody, LOC100136130 antibody, c9 antibody, wu:fb60b05 antibody, wu:fd50e04 antibody, zgc:112272 antibody, complement C9 antibody, complement component 9 antibody, complement component 9 L homeolog antibody, C9 antibody, c9 antibody, c9.L antibody

Background: C9 is synthesised in the liver and monocytes, and is a plasma protein consisting of a single polypeptide chain of molecular weight 71 kDa. Normal plasma concentration is 60 mg/L. C9 forms part of the membrane attack complex (MAC) the cytolytic terminal complex of the complement pathways. C9 binds to the membrane associated C5b-8, binding of C9 to C5b-8 leads to the circular polymerisation of 12-18 C9 Molecules. This is the basis of the hydrophilic, proteinwalled, trans-membrane channel formed by the MAC, which leads to cell lysis and destruction.Synonyms: Complement 9, Complement component C9

Gene ID: 735

NCBI Accession: NP_001728

UniProt: P02748

Pathways: Complement System