Cortactin antibody (N-Term)

Catalog No. ABIN951670

This Rabbit Polyclonal antibody specifically detects Cortactin in WB, IHC (p) and EIA. It exhibits reactivity toward Human.

Quick Overview for Cortactin antibody (N-Term) (ABIN951670)

Target: Cortactin (CTTN)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cortactin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-Cortactin Antibody

Binding Specificity: AA 16-46, N-Term

Specificity: This antibody recognizes Cortactin (SRC8) at N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Purified through a Protein A column followed by peptide affinity purification

Immunogen: Synthetic peptide - KLH conjugated - corresponding to the N-terminal region (between 16-46aa) of human Cortactin (SRC8)

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Cortactin

Target: Cortactin (CTTN)

Alternative Name: Cortactin

Background: SRC8 (CTTN) is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This protein has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this protein contributes to tumor cell invasion and metastasis.Synonyms: Amplaxin, CTTN, EMS1, Oncogene EMS1

Gene ID: 2017

NCBI Accession: NP_005222

Pathways: MAPK Signaling