CRH antibody (C-Term)

Catalog No. ABIN951671

Product Details anti-CRH Antibody

Target: CRH (Corticotropin Releasing Hormone (CRH))

Binding Specificity: C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRH antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes Human Corticoliberin (C-term).

Purification: Affinity Chromatography on Protein A

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CRH

Target: CRH (Corticotropin Releasing Hormone (CRH))

Alternative Name: Corticoliberin (CRH Products)

Synonyms: CRF antibody, Gm1347 antibody, crf antibody, crh antibody, zgc:101864 antibody, CRH antibody, corticoliberin antibody, crhb antibody, crh.1-a antibody, crha antibody, corticotropin releasing hormone antibody, corticotropin releasing hormone b antibody, corticotropin releasing hormone S homeolog antibody, corticotropin releasing hormone L homeolog antibody, Crh antibody, CRH antibody, crhb antibody, crh antibody, crh.S antibody, crh.L antibody

Background: Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition.Synonyms: CRF, CRH, Corticotropin-Releasing Factor, Corticotropin-Releasing Hormone

Molecular Weight: 21422 Da

Gene ID: 1392

NCBI Accession: NP_000747

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Activity, Negative Regulation of Hormone Secretion, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Feeding Behaviour