WHSC2 antibody (Middle Region)

Catalog No. ABIN953645

Product Details anti-WHSC2 Antibody

Target: WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))

Binding Specificity: AA 261-290, Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WHSC2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects NELF-A (Center).

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein A column followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 261-290 amino acids from the Central region of human WHSC2

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

Target Details for WHSC2

Target: WHSC2 (Wolf-Hirschhorn Syndrome Candidate 2 (WHSC2))

Alternative Name: NELF-A (WHSC2 Products)

Synonyms: BcDNA:SD07139 antibody, CG5874 antibody, Dmel\\CG5874 antibody, NELF antibody, NELF-A antibody, Whsc2 antibody, fi75f03 antibody, whsc2 antibody, wu:fi75f03 antibody, MGC85474 antibody, WHSC2 antibody, nelfa antibody, nelf-a antibody, p/okcl.15 antibody, Whsc2h antibody, Negative elongation factor A antibody, negative elongation factor complex member A antibody, negative elongation factor complex member A L homeolog antibody, negative elongation factor complex member A, Whsc2 antibody, Nelf-A antibody, Nelfa antibody, nelfa antibody, nelfa.L antibody, NELFA antibody

Background: This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93 % sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.Synonyms: NELFA, Negative elongation factor A, P/OKcl.15, WHSC2

Gene ID: 7469

NCBI Accession: NP_005654

Pathways: Chromatin Binding