PLGF antibody (AA 24-158)

Catalog No. ABIN954169

Product Details anti-PLGF Antibody

Target: PLGF (PGF) (Placenta Growth Factor (PGF))

Binding Specificity: AA 24-158

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLGF antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: Recognizes PlGF.

Cross-Reactivity (Details): Species reactivity (tested):Mouse.

Purification: Protein A Chromatography

Endotoxin Level: < 0.1 EU/1 μg of the antibody (LAL)

Immunogen: Highly pure (>95%) recombinant Mouse PlGF (Ala24-Pro158) derived from Sf9 insect cells.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Centrifuge vial prior to opening. Restore in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS, pH 7.2

Storage: 4 °C/-20 °C

Storage Comment: The lyophilized antibody is stable at RT for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C. Avoid repeated freeze-thaw cycles!

Expiry Date: 6 months

References for anti-PLGF antibody (ABIN954169)

Bader, Hsu: "Inactivation of the tumor suppressor gene von Hippel-Lindau (VHL) in granulocytes contributes to development of liver hemangiomas in a mouse model." in: BMC cancer, Vol. 16, Issue 1, pp. 797, (2017) (PubMed).

Target Details for PLGF

Target: PLGF (PGF) (Placenta Growth Factor (PGF))

Alternative Name: Placenta Growth Factor / PGF (PGF Products)

Synonyms: D12S1900 antibody, PGFL antibody, PLGF antibody, PlGF-2 antibody, SHGC-10760 antibody, AI854365 antibody, PIGF antibody, Plgf antibody, PlGF antibody, placental growth factor antibody, placenta growth factor antibody, PGF antibody, Pgf antibody, PLGF antibody

Background: Placenta growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family of growth factors. PlGF and VEGF share primary structural as well as limited amino acid sequence homology with the A and B chains of PDGF. All eight cysteine residues involved in intra and interchain disulfides are conserved among these growth factors. As a result of alternative splicing, three PlGF RNAs encoding monomeric human PlGF1, PlGF2 and PlGF3 isoform precursors containing 149, 179 and 219 amino acid residues, respectively, have been described. In normal mouse tissues, only one mouse PlGF mRNA encoding the equivalent of human PlGF2 has been identified. Mouse PlGF shares 65 % amino acid identity with human PlGF2. The gene for PlGF has been mapped to mouse chromosome 12 and human chromosome 14. PlGF binds with high affinity to Flt1, but not to Flk1/KDR.Synonyms: PGFL, PLGF, PlGF

Gene ID: 18654

NCBI Accession: NP_032853

Pathways: VEGFR1 Specific Signals