SSRP1 antibody (C-Term)

Catalog No. ABIN954958

This Rabbit Polyclonal antibody specifically detects SSRP1 in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for SSRP1 antibody (C-Term) (ABIN954958)

Target: SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SSRP1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-SSRP1 Antibody

Binding Specificity: AA 489-518, C-Term

Specificity: This antibody recognizes Human SSRP1 / FACT80 (C-term).

Purification: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 489-518 amino acids from the C-terminal region of Human SSRP1. Genename: SSRP1

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SSRP1

Target: SSRP1 (Structure Specific Recognition Protein 1 (SSRP1))

Alternative Name: SSRP1 / FACT80

Background: The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known.Synonyms: Chromatin-specific transcription elongation factor 80 kDa subunit, FACT 80 kDa subunit, FACT complex subunit SSRP1, FACTp80, Facilitates chromatin transcription complex subunit SSRP1, Recombination signal sequence recognition protein 1, Structure-specific recognition protein 1, T160

Molecular Weight: 81075 Da

Gene ID: 6749

NCBI Accession: NP_003137

Pathways: Chromatin Binding