TIE1 antibody (AA 22-748)

Catalog No. ABIN955208

This Rabbit Polyclonal antibody specifically detects TIE1 in WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for TIE1 antibody (AA 22-748) (ABIN955208)

Target: TIE1 (tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TIE1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-TIE1 Antibody

Binding Specificity: AA 22-748

Cross-Reactivity (Details): Species reactivity (tested):Human and Mouse.

Purification: Protein A Chromatography

Immunogen: Highly pure (>95%) recombinant Mouse soluble TIE-1 (Ser22-Ala748) derived from Insect cells.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Centrifuge vial prior to opening. Restore in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS, pH 7.2

Storage: 4 °C/-20 °C

Storage Comment: The lyophilized antibody is stable at RT for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C. Avoid repeated freeze-thaw cycles!

Expiry Date: 6 months

Target Details for TIE1

Target: TIE1 (tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1))

Alternative Name: TIE1

Background: TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis.Synonyms: TIE, Tie-1, Tyrosine-protein kinase receptor Tie-1

Gene ID: 10090

Pathways: RTK Signaling