RUNX1T1 antibody

Catalog No. ABIN965546

There is 1 publication for this product available. The Rabbit Polyclonal anti-RUNX1T1 antibody is suitable to detect RUNX1T1 in samples from Human. It has been validated for IHC.

Quick Overview for RUNX1T1 antibody (ABIN965546)

Target: RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RUNX1T1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Product Details anti-RUNX1T1 Antibody

Purification: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human AML1-MTG8(acute myelogenous leukemia 1 translocation 1 protein isoform MTG8c)

Application Details

Application Notes: ELISA, Western blotting: 1µg/ml for 2hrs.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

References for anti-RUNX1T1 antibody (ABIN965546)

Martinez, Drescher, Riehle, Cullmann, Vornlocher, Ganser, Heil, Nordheim, Krauter, Heidenreich: "The oncogenic fusion protein RUNX1-CBFA2T1 supports proliferation and inhibits senescence in t(8;21)-positive leukaemic cells." in: BMC cancer, Vol. 4, pp. 44, (2004) (PubMed).

Target Details for RUNX1T1

Target: RUNX1T1 (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1))

Alternative Name: AML1-MTG8

Background: AML1-MTG8(acute myelogenous leukemia 1 translocation 1 protein isoform MTG8c) is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.